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PRP RESEARCH

GENERAL ARTICLES

The biology of platelet-rich plasma and its application in trauma and orthopaedic surgery: a review of the literature.
J Bone Joint Surg Br; 2009 Aug;91(8):987-96

Focused Review: Current Trends in Platelet-Rich Plasma Injection Treatments
Journal of Neurosurgical Review, Vol 1 (2011).

Platelet-rich plasma: current concepts and application in sports medicine.
J Am Acad Orthop Surg; 2009 Oct;17(10):602-8

Regenerative injection therapy for osteoarthritis: fundamental concepts and evidence-based review
American Academy of Physical Medicine and Rehabilitation. PM R. 2012 May;4(5 Suppl):S104-9

Optimization of ingredients, procedures and rehabilitation for platelet-rich plasma injections for chronic tendinopathy
Future Medicine, 2011

The role of platelet-rich plasma in tissue regeneration
Informa Healthcare May 30, 2012

Platelet-Rich Plasma: A Milieu of Bioactive Factors
Arthroscopy: The Journal of Arthroscopic and Related Surgery, 2012

Applications of Platelet-Rich Plasma in Musculoskeletal and Sports Medicine: An Evidence-Based Approach
PM&R; 2011 Mar; 3(3): 226-250.

Musculoskeletal Applications of Platelet-Rich Plasma: Fad or Future? AJR Am J Roentgenol. 2011 Mar;196(3):628-36.

Platelet rich plasma injection grafts for musculoskeletal injuries: a review
Curr Rev Musculoskelet Med. 2008 Dec;1(3-4):165-74.

Platelet Rich Plasma Grafts in Musculoskeletal Medicine
Journal of Prolotherapy. 2010 May; 2(2): 371-376.

Platelet Rich Plasma (PRP) Matrix Grafts.
Practical Pain Management 2008:8 (1):11-26.

Platelet-rich plasma: current concepts and application in sports medicine
J Am Acad Orthop Surg. 2009 Oct;17(10):602-8.

Platelet-rich therapies in the treatment of orthopaedic sport injuries Sports Med. 2009;39(5):345-54

The Roles of Growth Factors in Tendon and Ligament Healing
Sports Med. 2003 33(5):381-394

Use of platelet-rich plasma in the care of sports injuries: our experience with ultrasound-guided injection.
PM 2013 Jul 3

Use of autologous platelet-rich plasma to treat muscle strain injuries. Am J Sports Med; 2009 Jun;37(6):1135-42

Platelet-Rich Plasma in Muscle Healing
American Journal of Physical Medicine & Rehabilitation: October 2010 – Volume 89 – Issue 10 – pp 854-861.

Treatment of Tendon and Muscle Using Platelet-Rich Plasma
Clin Sports Med 28(1): 113-25.

Treatment of muscle injuries by local administration of autologous conditioned serum: a pilot study on sportsmen with muscle strains
Int J Sports Med, 2004. 25:589-594.

Use of autologous platelet-rich plasma to treat muscle strain injuries
American Journal of Sports Med, 2009. 37 (6): 1135-1142.


SPINE

Lumbar Intradiskal Platelet-Rich Plasma (PRP) Injections: A Prospective, Double-Blind, Randomized Controlled Study
Physical Medicine and Rehabilitation, 2016, Jan; 8(1): 1-10.

An experimental study on effect of autologous platelet-rich plasma on treatment of early intervertebral disc degeneration.
Zhongguo Xiu Fu Chong Jian Wai Ke Za Zhi. 2012 Aug;26(8):977-83

Proliferation of Annulus Fibrosus Cells in Platelet Rich Plasma A Natural 3D Scaffold: An in Vitro Study: Gp8
Spine: Affiliated Society Meeting Abstracts . Supplement 1, October 2011.


SHOULDER

“Regenerative medicine in rotator cuff injuries.”
Biomed Res Int. 2014;2014:129515.

“Effectiveness of Platelet-rich Plasma Injection for Rotator Cuff Tendinopathy: A Prospective Open-label Study.”
Glob Adv Health Med. 2013 Mar;2(2):26-31.

” Intralesional injection of partial thickness rotator cuff tears”
Paper presented at 2014 RSNA meeting in Chicago

Use of Platelet Rich Plasma For The Treatment Of Bicipital Tendinopathy In Spinal Cord Injury: A Pilot Study
Br J Sports Med 2013;47:e2 doi:10.1136/bjsports-2013-092459.39.

PRP May Be Effective Treatment for RCT
American Academy of Orthopaedic Surgeons. 2013 Annual Meeting News February 19 – 23, 2013.

Platelet-rich plasma protects rotator cuff-derived cells from the deleterious effects of triamcinolone acetonide.
J Orthop Res. 2012 Dec 31. doi: 10.1002/jor.22301.

Comparison of the therapeutic effects of ultrasound-guided platelet-rich plasma injection and dry needling in rotator cuff disease: a randomized controlled trial.
Clin Rehabil. 2012 Oct 3.
Comparative Studies of Platelet-Rich Plasma (PRP) and Prolotherapy for Proximal Biceps Tendinitis.
Clin Should Elbow. 2011 Dec;14(2):153-158

Platelet-Rich Plasma Stimulates Cell Proliferation and Enhances Matrix Gene Expression and Synthesis in Tenocytes From Human Rotator Cuff Tendons With Degenerative Tears.
Am J Sports Med. 2012 Feb 23.

Clinical Indications and Techniques for the Use of Platelet-Rich Plasma in the Shoulder
Operative Techniques in Sports Medicine, Volume 19, Issue 3, September 2011, Pages 165-169.


ELBOW

“Efficacy of platelet-rich plasma for chronic tennis elbow: a double-blind, prospective, multicenter, randomized controlled trial of 230 patients.”
Am J Sports Med. 2014 Feb;42(2):463-71.

“Comparative effectiveness of injection therapies in lateral epicondylitis: a systematic review and network meta-analysis of randomized controlled trials.”
Am J Sports Med. 2013 Jun;41(6):1435-46.

“Treatment of partial ulnar collateral ligament tears in the elbow with platelet rich plasma”
Am J Sports Med. 2013 Jul;41(7):1689-1694.

Platelet-Rich Plasma Significantly Improves Clinical Outcomes in Patients With Chronic Tennis Elbow: A Double-Blind, Prospective, Multicenter, Controlled Trial of 230 Patients
Am J Sports Med July 3, 2013

Positive Effect of an Autologous Platelet Concentrate in Lateral Epicondylitis in a Double-Blind Randomized Controlled Trial: Platelet-Rich Plasma Versus Corticosteroid Injection With a 1-Year Follow-up
Am J Sports Med 38: 255-262
Treatment of chronic elbow tendinosis with buffered platelet-rich plasma
Am J Sports Med. 2006 Nov;34(11):1774-8.
Autologous blood injections for refractory lateral epicondylitis
Am J Hand Surg. 2003;28(2):272–8.

Platelet Rich Plasma Significantly Improves Clinical Outcomes in Patients with Chronic Tennis Elbow
The Orthobiologic Institute, March, 2013.
Treatment of chronic tendinopathy with ultrasound-guided needle tenotomy and platelet-rich plasma injection
PM R 2011 Oct; 3(10):900-11.

Clinical Indications and Techniques for the Use of Platelet-Rich Plasma in the Elbow
Operative Techniques in Sports Medicine, 2011

Treatment of Chronic Tendinopathy with Ultrasound-Guided Needle Tenotomy and Platelet-Rich Plasma Injection
PM R. 2011 Aug 25.
Ongoing Positive Effect of Platelet-Rich Plasma Versus Corticosteroid Injection in Lateral Epicondylitis: A Double-Blind Randomized Controlled Trial With 2-Year Follow-Up
Am J Sports Med; 2011 Mar.

Platelet-rich Plasma Injection Reduces Pain in Patients With Recalcitrant Epicondylitis
Orthopedics, February 2011.
A systematic review of four injection therapies for lateral epicondylosis: prolotherapy, polidocanol, whole blood and platelet-rich plasma.
Br J Sports Med; 2009 Jul;43(7):471-81.


HAND / WRIST

“Stem cells and biological approaches to treatment of wrist problems.”
J Wrist Surg. 2013 Nov;2(4):315-8.


HIP

“Efficacy of ultrasound-guided intra-articular injections of platelet-rich plasma versus hyaluronic acid for hip osteoarthritis.”
Orthopedics. 2013 Dec;36(12):e1501-8.

“Hip osteoarthritis in dogs: a randomized study using mesenchymal stem cells from adipose tissue and plasma rich in growth factors.”
Int J Mol Sci. 2014 Jul 31;15(8):13437-60.

Platelet-Rich Plasma (PRP): an adjuvant to hasten hamstring muscle recovery. A randomized controlled trial protocol (ISCRTN66528592) BioMedCentral 2012

Platelet-rich Plasma as an Effective Treatment for Proximal Hamstring Injuries.
Orthopedics. 2013 Jan 1;36(1):e64-70.

Treatment of a hip capsular injury in a professional soccer player with platelet-rich plasma and bone marrow aspirate concentrate therapy.
Knee Surg Sports Traumatol Arthrosc.

Ultrasound-guided platelet-rich plasma injections for the treatment of osteoarthritis of the hip
Rheumatology (2011) doi: 10.1093/rheumatology/ker303.


KNEE

“Effect of leukocyte concentration on the efficacy of platelet rich plasma in the treatment of knee osteoarthritis”
American J Of Sports Med. March 2016. 44(3): 792-800.

“Efficacy of Intra-articular PRP Injections In Knee Osteoarthritis : A Systematic Review”
Arthroscopy. Mar 2016. 32(3). Pp 495-505.

“Viscosupplementation for Osteoarthritis of the Knee: A Systematic Review of the Evidence”
JBJS. 2015 Dec 16; 97(24): 2047-60.

“Effect of leukocyte concentration on the efficacy of platelet rich plasma in the treatment of knee osteoarthritis”
American J Of Sports Med. March 2016. 44(3): 792-800.

“Efficacy of Intra-articular PRP Injections In Knee Osteoarthritis : A Systematic Review”
Arthroscopy. Mar 2016. 32(3). Pp 495-505.

“Viscosupplementation for Osteoarthritis of the Knee: A Systematic Review of the Evidence”
JBJS. 2015 Dec 16; 97(24): 2047-60.

“Adult human mesenchymal stem cells delivered via intra-articular injection to the knee following partial medial menisectomy: a randomized, double blind, controlled study.”
JBJS. 2014 Jan 15;96(2):90-98.

“Concentrated bone marrow aspirate improves full thickness cartilage repair compared with microfracture in the equine model”
JBJS. 2010 Aug 18;92(10):1927-1937.

Platelet-Rich Plasma Treatment in Symptomatic Patients With Knee Osteoarthritis: Preliminary Results in a Group of Active Patients
Sports Health: A Multidisciplinary Approach 2012 4: 162 originally published online 20 January 2012

Autologous platelet gel for tissue regeneration in degenerative disorders of the knee.
Blood Transfus. 2011 Oct 25:1-6. doi: 10.2450/2011.0026-11

Injection of Platelet-Rich Plasma in Patients with Primary and Secondary Knee Osteoarthritis: A Pilot Study
The American Journal of Physical Medicine & Rehabilitation. Nov 20, 2010 online. Print Dec 2010.

Treatment of Knee Joint Osteoarthritis with Autologous Platelet-Rich Plasma in Comparison with Hyaluronic Acid American Journal of Physical Medicine & Rehabilitation 0894-9115/12/9104-0000/0

“Regenerative repair of damaged meniscus with autologous adipose tissue-derived stem cells.”
Biomed Res Int. 2014;2014:436029.

“Knee Osteoarthritis Injection Choices: Platelet- Rich Plasma (PRP) Versus Hyaluronic Acid (A one-year randomized clinical trial).”
Clin Med Insights Arthritis Musculoskelet Disord. 2015 Jan 7;8:1-8.

“Does intra articular platelet rich plasma injection improve function, pain, and quality of life in patients with osteoarthritis of the knee? A randomized clinical trial. ”
Orthop Rev (Pavia). 2014 Sep 18;6(3):5405.

Intraarticular Platelet-Rich Plasma Injection in the Treatment of Knee Osteoarthritis: Review and Recommendations.
American Journal of Physical Medicine and Rehabilitation, May 29, 2014

Platelet-Rich Plasma Added to the Patellar Tendon Harvest Site During Anterior Cruciate Ligament Reconstruction Enhanced Healing
Am J Sports Med. 2012 Jun;40(6):1282-8.

Clinical and MRI Outcomes After Platelet-Rich Plasma Treatment for Knee Osteoarthritis.
Clin J Sport Med. 2012 Dec 12.

Use of platelet-rich plasma for the treatment of refractory jumper’s knee
International Orthopaedics; 31 July 2009; Vol 24, No 6; 909-915

Platelet-rich plasma: New clinical application: A pilot study for treatment of jumper’s knee
International Journal of the Care of the Injured; 2009 June; 40(6): 509-603

Platelet-Rich Plasma Injection for Partial Patellar Tendon Tear in a High School Athlete: A Case Presentation American Academy of Physical Medicine and Rehabilitation, Vol. 3, 391-395, April 2011.

Intraarticular Platelet-Rich Plasma Injection in the Treatment of Knee Osteoarthritis: Review and Recommendations.
American Journal of Physical Medicine and Rehabilitation, May 29, 2014

The Use of Platelet-Rich Plasma in Degenerative Lesions of the Knee: Results at Two-year Follow Up
OASIS, Mar 20, 2013.

Treatment With Platelet-Rich Plasma Is More Effective Than Placebo for Knee Osteoarthritis
AJSM PreView, January 8, 2013

Infiltration of plasma rich in growth factors for osteoarthritis of the knee short-term effects on function and quality of life
Arch Orthop Trauma Surg, Springer-Verlag 2010

Platelet rich plasma intra-articular injections: a new therapeutic strategy for the treatment of knee osteoarthritis in sport rehabilitation. A systematic review
Sport Sci Health (2012) 8:15–22

Platelet-Rich Plasma Treatment in Symptomatic Patients With Knee Osteoarthritis: Preliminary Results in a Group of Active Patients
Sports Health: A Multidisciplinary Approach 2012 4: 162 originally published online 20 January 2012
Treatment of Knee Joint Osteoarthritis with Autologous Platelet-Rich Plasma in Comparison with Hyaluronic Acid
American Journal of Physical Medicine & Rehabilitation

Autologous platelet gel for tissue regeneration in degenerative disorders of the knee.
Blood Transfus. 2011 Oct 25:1-6. doi: 10.2450/2011.0026-11.

Platelet-Rich Plasma Intra-Articular Injection Versus Hyaluronic Acid Viscosupplementation as Treatments for Cartilage Pathology: From Early Degeneration to Osteoarthritis
Arthroscopy. 2011 Aug 8.

The Effects of Platelet-Rich Plasma on Cartilage: Basic Science and Clinical Application
Operative Techniques in Sports Medicine, Volume 19, Issue 3, September 2011, Pages 154-159.

Platelet-Rich Plasma Releasate Inhibits Inflammatory Processes in Osteoarthritic Chondrocytes
The American Journal of Sports Medicine; August 19, 2011

Injection of Platelet-Rich Plasma in Patients with Primary and Secondary Knee Osteoarthritis: A Pilot Study
American Journal of Physical Medicine & Rehabilitation. Dec 2010. 961-969.

Infiltration of plasma rich in growth factors for osteoarthritis of the knee short-term effects on function and quality of life
Archives of Orthopaedic and Trauma Surgery, Volume 131, Number 3, 311-317

The regenerative effect of platelet-rich plasma on healing in large osteochondral defects
International Orthopaedics, 2010. 34:589-597.

Platelet-rich plasma: intra-articular knee injections produced favorable results on degenerative cartilage lesions
Knee Surg Sports Traumatol Arthrosc. Sept 2009: 0940-8.

Tissue Engineering with Platelet-Rich Plasma and Stem Cells: New Frontier In Rheumatology
The Journal of Musculoskeletal Medicine. July 2009.

Plasma rich in growth factors to treat an articular cartilage avulsion: a case report
Med Sci Sports Exerc 2003, 35:1648-1652.

Platelet-rich plasma application during closure following total knee arthroplasty
Orthopedics. 2006;29(7):590–8.

The efficacy of autologous platelet gel in pain control and blood loss in total knee arthroplasty: an analysis of the haemoglobin, narcotic requirement and range of motion
Int Orthop. 2006;31:309–13.

Platelet gel and fibrin sealant reduce allogeneic blood transfusions in total knee arthroplasty
Acta Anaesthesiol Scand. 2006;50:593–9.

A Randomized Clinical Trial Evaluating Plasma Rich in Growth Factors (PRGF-Endoret) Versus Hyaluronic Acid in the Short-Term Treatment of Symptomatic Knee Osteoarthritis
(2012) Arthroscopy – Journal of Arthroscopic and Related Surgery, 28 (8), pp. 1070-1078.

Ultrasound-guided platelet-rich plasma injections for the treatment of common peroneal nerve palsy associated with multiple ligament injuries of the knee
Knee Surgery, Sports Traumatology, Arthroscopy Online ISSN 1433-7347.


FOOT / ANKLE

“Plasma rich in growth factors (PRGF) as a treatment for high ankle sprain in elite athletes: a randomized control trial.”
Knee Surg Sports Traumatol Arthrosc. 2014 Jun 18

“A single platelet-rich plasma injection for chronic midsubstance achilles tendinopathy: a retrospective preliminary analysis.”
Foot Ankle Spec. 2014 Oct;7(5):372-6.

Platelet-rich plasma therapy as a first-line treatment for severe Achilles tendon tear: a case report
International Journal of Therapy and Rehabilitation. February 2011, Vol 18, No 2.

Platelet Rich Plasma and Plantar Fasciitis Sports Medicine and Arthroscopy Review. Dec 2013

The treatment of intractable plantar fasciitis with platelet-rich plasma injection.
Foot. 2013 Jul 29.

Autologous Platelet-Rich Plasma Versus Dextrose Prolotherapy for the Treatment of Chronic Recalcitrant Plantar Fasciitis.
PM R. 2013 Jul 19.

Platelet-rich plasma injections for chronic plantar fasciitis.
Int Orthop. 2012 Dec 19.

Platelet rich plasma treatment for chronic achilles tendinosis.
Foot Ankle Int. 2012 May;33(5):379-85.

Platelets rich plasma for treatment of chronic plantar fasciitis.
Arch Orthop Trauma Surg. 2012 May 4

Platelet-Rich Rich Plasma is More Effective than Cortisone for Chronic Severe Plantar Fasciitis 2012 Annual American Academy of Orthopaedic Surgeons meeting Podium Presentations.

The Use of Platelet-Rich Plasma in the Management of Foot and Ankle Conditions
Operative Techniques in Sports Medicine, Volume 19, Issue 3, September 2011, Pages 177-184.

Injection Techniques of Platelet-Rich Plasma Into and Around the Achilles Tendon: A Cadaveric Study
Am J Sports Med, April 19 2011.

Platelet-rich plasma therapy as a first-line treatment for severe Achilles tendon tear: a case report
International Journal of Therapy and Rehabilitation. February 2011, Vol 18, No 2.

Treatment of Achilles Tendinopathy with Platelet RichPlasma
International Journal of Sports Med, June 2010.

Platelet-Rich Plasma Injection for Chronic Achilles Tendinopathy: A Randomized Controlled Study JAMA 2010, 3003(2): 144-149.

Platelet Rich Plasma (PRP) Effectively Treats Chronic Achilles Tendinosis
2010 Annual American Academy of Orthopaedic Surgeons meeting Podium Presentations.

Platelet-rich plasma (PRP) in managing Achilles tendinosis
2010 Annual American Orthopaedic Foot & Ankle Society (AOFAS) Meeting.

Nonoperative Biological Treatment Approach for partial Achilles Tendon Lesion Orthopedics 1;33(2):120-3.

Growth factors for chronic plantar fasciitis
Podiatry Today 2004;17:37.


BASIC SCIENCE

Effect of autologous platelet-rich plasma-releasate on intervertebral disc degeneration in the rabbit anular puncture model: a preclinical study
Arthritis Research & Therapy 2012, 14:R241

Comparison of the Acute Inflammatory Response of Two Commercial Platelet-Rich Plasma Systems in Healthy Rabbit Tendons
Am J Sports Med. 2012 April 10.

Experimental model for the study of the effects of platelet-rich plasma on the early phases of muscle healing.
PM 2013 Jun 19

The Effects of Platelet-Rich Plasma on Muscle: Basic Science and Clinical Application
Operative Techniques in Sports Medicine, Volume 19, Issue 3, September 2011, 149-153.

Effect of platelet-rich plasma on tendon healing
Zhongguo Xiu Fu Chong Jian Wai Ke Za Zhi. Mar 2011; 25(3):344-8.

Chondrogenesis in cartilage repair is induced by members of the transforming growth factor-beta superfamily
Clin Orthop Relat Res. 2001;391(Suppl):S171–81.

Platelet-released growth factors enhance the secretion of hyaluronic acid and induce hepatocyte growth factor production by synovial fibroblasts from arthritic patients
Rheumatology. 2007;46(12):1769–72.

Autologous injectable tissue-engineered cartilage by using platelet-rich plasma: experimental study in a rabbit model. [Journal Article, Research Support, Non-U.S. Gov’t]
J Oral Maxillofac Surg 2007 Oct; 65(10):1951-7.

Platelet concentrate injection improves Achilles tendon repair in rats
Acta Orthop Scand 75(1):93-9.

Platelet quantification and growth factor analysis from platelet-rich plasma: implications for wound healing
Plast Reconstr Surg. 2004 Nov;114(6):1502-8.