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RESEARCH BMA

BONE MARROW DERIVED STEM CELL RESEARCH ARTICLES

Percutaneous Injection of Autologous Bone Marrow Concentrate Cells Significantly Reduces Lumbar Discogenic Pain Through 12 Months
Stem Cells, Sept 3, 2014, 146-156.

Enhancing human nucleus pulposus cells for biological treatment approaches of degenerative intervertebral disc diseases: a systematic review
J Tissue Eng Regen Med 2014; 8: 925–936.

Multipotent Mesenchymal Stem Cell Treatment for Discogenic Low Back Pain and Disc Degeneration
Stem Cells International
Volume 2016 (2016), Article ID 3908389

Intervertebral Disc Repair by Autologous Mesenchymal Bone Marrow Cells: A Pilot Study
Transplantation 2011;92: 822–828

Tissue engineering strategies applied in the regeneration of the human intervertebral disk
http://dx.doi.org/10.1016/j.biotechadv.2013.07.010

Cell and molecular biology of intervertebral disc degeneration: current understanding and implications for potential therapeutic strategies
Cell Prolif., 2014, 47, 381–390

Cell sources for nucleus pulposus regeneration
Eur Spine J (2014) 23 (Suppl 3):S364–S374

Disc cell therapies: critical issues
Eur Spine J (2014) 23 (Suppl 3):S375–S384

Autologous Bone Marrow Concentrate: Review and Application of a Novel Intra-Articular Orthobiologic for Cartilage Disease
The Physician and Sports Medicine. 2013 Sep

Clinical Outcome of Autologous Bone Marrow Aspirates Concentrate Injection in Degenerative Arthritis of the Knee
European journal of Orthopaedic Surgery and Traumatology. 2014 Jan

Regenerative injection therapy with whole bone marrow aspirate for degenerative joint disease: a case series.
Clin Med Insights Arthritis Musculoskelet Disord. 2013 Sep 4

Mesenchymal stem cells for the treatment of cartilage lesions: from preclinical findings to clinical application in orthopaedics.
Knee Surg Sports Traumatol Arthrosc. 2013 Jan 11.

Treatment of Knee Osteoarthritis With Autologous Mesenchymal Stem Cells: A Pilot Study
Transplantation: 27 June 2013 – Volume 95 – Issue 12 – p 1535–1541

Intra-articular injection of mesenchymal stem cells for the treatment of osteoarthritis of the knee: a proof-of-concept clinical trial.
Stem Cells. 2014 May;32(5):1254-66. doi: 10.1002/stem.1634.

Stem Cell Therapy Following Meniscus Knee Surgery May Reduce Pain, Restore Meniscus
Read more: http://www.digitaljournal.com/pr/1686326#ixzz4JOzZgCJV

Adult Human Mesenchymal Stem Cells Delivered via Intra-Articular Injection to the Knee Following Partial Medial Meniscectomy
J Bone Joint Surg Am, 2014 Jan 15; 96 (2): 90 -98 . http://dx.doi.org/10.2106/JBJS.M.00058

You may not be better off after knee surgery
http://www.cnn.com/2013/12/26/health/knee-surgery-study/index.html

Arthroscopic Partial Meniscectomy versus Sham Surgery for a Degenerative Meniscal Tear
N Engl J Med 2013; 369:2515-2524December 26, 2013DOI: 10.1056/NEJMoa1305189

Impacts of bone marrow aspirate and peripheral blood derived platelet-rich plasma on the wound healing in chronic ischaemic limb.
J Plast Surg Hand Surg. 2013 Apr 26.

Treatment of chronic patellar tendinopathy with autologous bone marrow stem cells: a 5-year-followup.
Stem Cells Int. 2012;2012:953510. doi: 10.1155/2012/953510. Epub 2011 Dec 18.

Effects of intra-articular administration of autologous bone marrow aspirate on healing of full-thickness meniscal tear: an experimental study on sheep.
Acta Orthop Traumatol Turc. 2012;46(1):61-7.

Clinical Use of Bone Marrow, Bone Marrow Concentrate, and Expanded Bone Marrow Mesenchymal Stem Cells in Cartilage Disease.
Stem Cells Dev. 2012 Nov 16. PMID: 23030230

Establishing proof of concept: Platelet-rich plasma and bone marrow aspirate concentrate may improve cartilage repair following surgical treatment for osteochondral lesions of the talus
World J Orthop 2012 July 18; 3(7): 101-108

Benefits of small volume and small syringe for bone marrow aspirations of mesenchymal stem cells.
Int Orthop. 2013 Jul 24.

Safety of autologous bone marrow aspiration concentrate transplantation: initial experiences in 101 patients.
Orthop Rev (Pavia). 2009 October 10; 1(2): e32. Doi: 10.4081/or.2009.e32

Stem cells and cartilage development: complexities of a simple tissue.
Stem Cells 2010, 28:1992-1996.

Cartilage tissue engineering: towards a biomaterial assisted mesenchymal stem cell therapy.
Curr Stem Cell Res Ther 2009, 4:318-329.

Chondrogenesis and cartilage tissue engineering: the longer road to technology development.
Trends Biotechnol 2012, 30:166-176

Concise Review: The Clinical Application of Mesenchymal Stem Cells for Musculoskeletal Regeneration: Current Status and Perspectives.
Stem Cells Translational Medicine 2012; 1:237-247

Different populations and sources of human mesenchymal stem cells (MSC): a comparison of adult and neonatal tissue-derived MSC.
Cell Commun Signal 2011, 9:12

Adult mesenchymal stem cells for tissue engineering versus regenerative medicine.
J Cell Physiol 2007, 213:341-347.

Marrow stromal cells as stem cells for nonhematopoietic tissues.
Science 1997, 276:71-74.

Multilineage potential of adult human mesenchymal stem cells.
Science 1999,284:143-147.

A small proportion of mesenchymal stem cells strongly expresses functionally active CXCR4 receptor capable of promoting migration to bone marrow.
Blood 2004, 104:2643-2645.

Treatment of a hip capsular injury in a professional soccer player with platelet-rich plasma and bone marrow aspirate concentrate therapy. Knee Surg Sports Traumatol Arthrosc.

Articular cartilage and subchondral bone in the pathogenesis of osteoarthritis.
Ann N Y Acad Sci 2010, 1192:230-237.

The impact of osteoarthritis: implications of research.
Clin Orthop Relat Res 2004, (427 Suppl):S6-S15

Stem cell therapy for cartilage regeneration in osteoarthritis.
Expert Opin Biol Ther 2009, 9:1399-1405.

Future Directions for Research and Treatments of Osteoarthritis
Frontiers in Bioscience 4, d762-771, October 15, 1999

Intraarticular treatments for osteoarthritis: new perspectives
Curr Drug Targets 2010, 11:546-560.

Mesenchymal stem cells for cartilage repair in osteoarthritis.
Stem Cell Research & Therapy 2012, 3:25 doi: 10.1186/scrt116

Mesenchymal stem cells in arthritic diseases.
Arthritis Res Ther 2008, 10:223.

Mesenchymal stem-cell based HLA-independent cell therapy for tissue engineering of bone and cartilage.
Curr stem Cell Res Ther 2006, 1:21-27

Stem Cells and other innovative intra-articular therapies for osteoarthritis: What does the future hold?
BMC Medicine 2012, 10:44

Repair of articular cartilage defects in the patello-femoral joint with autologous bone marrow mesenchymal cell transplantation: three case reports involving nine defects in five knees.
J Tissue Eng Regen Med 2007, 1:74-79

Autologous bone marrow-derived mesenchymal stem cells versus autologous chondrocyte implantation: an observational cohort study.
Am J Sports Med 2010, 38:1110-1116.

Mesenchymal stem cell therapy for knee osteoarthritis. Preliminary report of four patients.
Int J Rheum Dis 2011, 14:211-215.

Intra-articular injection of Autologous Mesenchymal Stem Cells in Six patients with Knee Osteoarthritis
Arch Iran Med. 2012; 15(7): 422-428.

Autologous bone marrow mesenchymal stem cells implantation for cartilage defects: two case report.
J Med Assoc Thai 2011, 94:395-400.

Increased knee cartilage volume in degenerative joint disease using percutaneously implanted, autologous mesenchymal stem cells.
Pain Physician 2008, 11:343-353.

Regeneration of human bones in hip osteonecrosis and human cartilage in knee osteoarthritis with autologous adipose-tissue-derived stem cells: a case series
J Med Case Rep 2011, 5:296.

Treatment of osteonectrosis of the femoral head with implantation of autologous bone-marrow cells: A pilot study
J Bone Joint Surg Am. 2004 Jun; 86-A(6):1153-60.

Treatment of a full-thickness articular cartilage defect in the femoral condyle of an athlete with autologous bone-marrow stromal cells.
Osteoarthr Cartil 2007, 15:226-231.

The clinical use of human culture-expanded autologous bone marrow mesenchymal stem cells transplanted on platelet-rich fibrin glue in the treatment of articular cartilage defects: a pilot study and preliminary results.
Cartilage 2010, 1:253-261.

Establishing proof of concept: Platelet-rich plasma and bone marrow aspirate concentrate may improve cartilage repair following surgical treatment for osteochondral lesions of the talus
World J Orthop 2012 July 18; 3(7): 101-108

Bone marrow aspirate and bone allograft to treat acetabular bone defects in revision total hip arthroplasty: preliminary report.
Eur Rev Med Pharmacol Sci. 2013 Aug;17(16):2240-9.

Regenerate Augmentation with bone marrow concentrate after traumatic bone loss.
Orthopedic Reviews 2012; volume 4:e14

Percutaneous Autologous Bone-Marrow Grafting for Nonunions: Influence of the Number and Concentration of Progenitor Cells.
The Journal of Bone and Joint Surgery. 2005; 87:1430-1437

“Therapeutic Angiogenesis for Patients with Limb Ischemia by Autologous Transplantation of Bone Marrow Cells: A Pilot Study and Randomized Controlled Study”
The Lancet; 360:427-435; 2002

STEM CELL THERAPY FOR TENDINOPATHY: LESSONS FROM A LARGE ANIMAL MODEL
Br J Sports Med 2013;47:e2 doi:10.1136/bjsports-2013-092459.42

Autologous bone marrow mesenchymal stromal cells for regeneration of injured equine ligaments and tendons: A clinical report.
Res Vet Sci. 2013 Feb 16. pii: S0034-5288(13)00019-2. doi: 10.1016/j.rvsc.2013.01.017

Homing and reparative effect of intra-articular of autologous mesenchymal stem cells in osteoarthritis animal model.
BMC Musculoskelet Disord. 2011 Nov 15; 12:259.

Direct transplantation of mesenchymal stem cells into the knee joints of Hartley strain guinea pigs with spontaneous osteoarthritis.
Arthritis Res Ther. 2012 Feb 7;14(1):R31

Cell based therapy for osteoarthritis in a sheep model: gross and histological assessment.
Med J Malaysia 2008, 63(Suppl A):37-38.

Osteoarthritis treated with mesenchymal stem cells on hyaluronan-based scaffold in rabbit.
Tissue Eng Part C Methods 2009, 15:647-658.

Stem cell therapy in a caprine model of osteoarthritis.
Arthritis Rheum 2003, 48:3464-3474.

The restoration of full-thickness cartilage defects with BMSCs and TGF-beta 1 loaded PLGA/fibrin gel constructs.
Biomaterials 2010, 31:8964-8973

Bone marrow mesenchymal stem cells inhibit the response of naïve and memory antigen-specific T cells to their cognate peptide.
Blood May 1, 2003 vol. 101 no. 9 3722-3729

Characterization of proteoglycan production and processing by chondrocytes and BMSCs in tissue engineered constructs
Osteoarthr Cartil 2008, 16:1092-1100.

Concentrated bone marrow aspirate improves full-thickness cartilage repair compared with microfracture in the equine model.
J Bone Joint Surg Am. 2010 Aug 18; 92(10):1927-37

Impact of growth factors and PTHrP on early and lage chondrogenic differentiation of human mesenchymal stem cells.
J Cell Physiol 2010, 223:84-93.

Human mesenchymal stem cells modulate allogeneic immune cell responses.
Blood 2005, 105:1815-1822.

Chondrogenic differentiation of mesenchymal stem cells from bone marrow: differentiation-dependent gene expression of matrix components.
Exp Cell Res 2001, 268:189-200.

Comparison of effect of BMP-2, -4, and -6 on in vitro cartilage formation of human adult stem cells from bone marrow stroma.
Cell Tissue Res 2005, 320:269-276.